BRIEF PROJECT DESCRIPTION:
Background: Localized prostate cancer are treated with prostatectomy or radiotherapy but neither of them is a guarantee for eradication. Cancer patients always need routine check-up to monitor their PSA level and the state of an increasing PSA (>0.1ng/ml) is normally known as biochemical recurrence (BCR). During treatments, cancer cells are supposed to removed or effectively killed by radiation. But some cells might stay or spread outside the treatment areas before they could be removed or killed so after the treatment, they start to multiply and then produce enough PSA which could become detectable in the blood test.
Introduction: Imaging modalities including MRI, CT and ultrasound are all routine examinations for prostate cancer diagnosis and management. Nowadays, new imaging techniques have been applied from research to clinic field to better interpret prostate cancer, shear wave elastography has been added to ultrasound to quantitatively detect cancer, more MR sequences are introduced in multiparametric MRI scan as combined diagnosis. But how these current and new techniques could predict or avoid BCR after treatment is still unknown.
Aim and project: in this project, patients with treatment of prostatectomy and/or radiotherapy back to 2013 will be retrospectively recruited, all available imaging modalities will be recorded and analysed compared to patients following-up months and recurrence rate. medical models will be developed to evaluate patients’ possibility of BCR.
It is of course recognised that the content (and to some extent the expectations) of a project may change during its life cycle, however, at the outset, it is envisaged that the above project will involve the following elements in the approximate required weightings indicated.
Theory 25% Computational 25%
Design 30% Manufacturing 0%
Experimentation 20% Other (specify)
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